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Neuromodulators

Neuromodulators with Xeomin®

Natural Wrinkle Relaxation

Facial expressions are one of the most natural ways we communicate—smiling, concentrating, laughing, or squinting in the sun. Over time, however, these repeated movements can begin to leave visible lines on the skin.

Forehead lines, frown lines between the brows, and crow’s feet around the eyes are among the most common signs of facial aging. These lines often develop gradually as collagen levels change and facial muscles continue to contract thousands of times each day.

Many people begin to notice that these lines remain visible even when the face is at rest.

You may relate if:

  • Forehead lines remain visible even when your face is relaxed
  • You see deeper lines between your eyebrows when concentrating
  • Crow’s feet appear around the eyes when smiling
  • You feel your facial expression sometimes looks tired or stressed
  • You want natural-looking results without surgery or downtime


At Tone & Core in Lakewood Ranch, Florida, neuromodulator treatments are performed using Xeomin®, an FDA-approved injectable treatment used to relax targeted facial muscles that cause expression lines.

By temporarily reducing muscle activity in specific areas, Xeomin® helps smooth the skin and soften wrinkles while preserving natural facial movement.

The result is a refreshed, relaxed appearance that still looks like you.

All treatments are performed by appropriately trained and licensed providers under the direction and supervision of a licensed physician in accordance with Florida regulations governing medical aesthetic procedures.

Located in Lakewood Ranch, we welcome patients from Bradenton, Sarasota, Parrish, Palmetto, Fruitville, Siesta Key, and surrounding Gulf Coast communities.

Reserve your consultation today to learn whether Xeomin® neuromodulator treatment is right for you.

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What Is Xeomin®?

Xeomin® (incobotulinumtoxinA) is an FDA-approved neuromodulator used to temporarily improve the appearance of facial lines caused by repeated muscle movement.

These lines develop as facial muscles contract over time. Xeomin® works by relaxing the targeted muscles responsible for these movements.

As muscle activity decreases, the skin above those muscles begins to appear smoother and more relaxed.

Xeomin® is often referred to as a “purified” neuromodulator because it does not contain accessory proteins. This means the formulation contains only the active ingredient, which some patients and providers prefer.

Many patients choose Xeomin® for its:

Precision• Purity• Natural looking results

Individual results may vary.

Common Areas Treated with Xeomin®

Neuromodulators can be used to treat several areas of the face where expression lines commonly develop.

Common treatment areas include:

  • Forehead lines
  • Frown lines between the eyebrows (glabellar lines)
  • Crow’s feet around the eyes
  • Bunny lines on the nose (off-label use)
  • Chin dimpling (off-label use)
  • Lip flip (subtle upper lip relaxation — off-label use)
  • Jawline tension (masseter muscle — off-label use)

During your consultation, your provider will evaluate your facial anatomy and recommend a personalized treatment plan.

What to Expect During Your Xeomin® Treatment

Step 1 — Consultation

Every treatment at Tone & Core begins with a personalized consultation.

Your provider will:

Review your medical history

Evaluate facial muscle movement

Discuss your aesthetic goals

Determine whether neuromodulator treatment is appropriate

This consultation ensures treatment is safe, medically appropriate, and aligned with your desired outcome.

Step 2 — Treatment Planning

Your provider will identify the specific facial muscles responsible for the wrinkles being treated.

Injection points are carefully mapped to maintain facial balance and natural expression.

Step 3 — Xeomin® Injection

Using a very fine needle, small amounts of Xeomin® are injected into targeted facial muscles.

The treatment typically takes 10–20 minutes, depending on the number of areas treated.

Most patients describe the sensation as small pinches that are quick and well tolerated.

Step 4 — Muscle Relaxation

After treatment, Xeomin® begins working to relax the targeted muscles.

As muscle activity decreases, the skin above those muscles gradually smooths.

The goal is to soften expression lines while preserving natural facial movement.

Step 5 — Gradual Results

Results typically begin appearing within 3–5 days, with full results visible in about 10–14 days.

The effects generally last 3–4 months, after which muscle activity gradually returns.

Maintenance treatments can help maintain results over time.

Benefits of Neuromodulator Treatment

  • Temporarily softens forehead lines and expression wrinkles
  • Reduces frown lines between the brows
  • Improves the appearance of crow’s feet
  • Quick treatment with minimal downtime
  • Maintains natural facial movement
  • Helps create a refreshed, relaxed appearance

Neuromodulators are among the most commonly performed aesthetic treatments worldwide because they provide subtle yet effective results.

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The Transformation Many Patients Notice After Treatment

Many patients report that neuromodulator treatments help them appear:

  • More relaxed
  • More refreshed
  • More approachable
  • More confident

The goal is not to change how you look—but to help you look like a more rested version of yourself.

Results develop gradually: many notice softening of lines within days, with the full refreshed look apparent in 1–2 weeks. Effects typically last 3–4 months, with maintenance every 3–6 months to sustain the natural, confident appearance. Individual results may vary—no guarantees are made.

Why Patients Choose Tone & Core

At Tone & Core, aesthetic treatments are approached with the same standards as medical care—thoughtful, individualized, and grounded in evidence-based medicine.

Patients choose our clinic because they value:

  • Physician-led care under the supervision of a board-certified Family Medicine physician with advanced training in aesthetic medicine.
  • Evidence-based treatments selected for safety and effectiveness
  • Personalized treatment plans tailored to each patient’s anatomy and goals
  • Honest recommendations focused on natural results
  • Transparent communication and clear treatment plans


Our goal is not simply to offer treatments—but to provide guidance, clarity, and trusted medical partnership.

Tone & Core

Your Lakewood Ranch partner for lifelong health—rooted in trust and delivered with precision.

Frequently Asked Questions

Most treatments take 10–20 minutes, depending on the number of areas treated. The full appointment, including consultation review, is usually under 45 minutes.

Initial softening of lines may begin within 3–5 days, with full results typically visible within 10–14 days. The effects develop gradually for a natural transition.

Results typically last 3–4 months, though this can vary based on muscle strength, metabolism, dosage, and lifestyle. Many patients schedule maintenance every 3–6 months to keep the refreshed look consistent.

Most patients describe the injections as mild pinches or quick pricks. A very fine needle is used, and no anesthesia is typically needed. Many find it far less uncomfortable than expected.

Downtime is minimal to none. Most patients return to normal activities immediately. Mild redness or small injection marks may occur but usually resolve within hours. Avoid strenuous exercise or rubbing the area for 4–6 hours post-treatment.

Yes—Xeomin® pairs well with dermal fillers, microneedling, chemical peels, or skin rejuvenation treatments for comprehensive results. We’ll discuss safe combinations during your consultation.

Most patients maintain results with treatments every 3–4 months. Some find intervals can extend to 4–6 months with consistent use. Your provider will tailor timing based on your response.

Xeomin® is FDA-approved and has a strong safety profile when administered by trained professionals. It has been widely studied for cosmetic and medical uses. Serious side effects are rare; common ones (e.g., mild bruising, headache) are temporary.

Side effects are usually mild and short-lived, including:

  • Redness, swelling, or bruising at injection sites
  • Mild headache (rare, usually within 24–48 hours)
  • Temporary eyelid drooping or asymmetry (uncommon, resolves as effects wear off)

All risks are reviewed during consultation.

Xeomin® may not be suitable if you have neuromuscular disorders (e.g., ALS, myasthenia gravis), allergies to botulinum toxin products, active skin infections at the site, or are pregnant/breastfeeding. A full medical history review ensures safety.

This varies by area, muscle strength, and goals. Typical ranges:

  • Forehead: 10–30 units
  • Frown lines: 15–30 units
  • Crow’s feet: 10–25 units per side

Your provider will assess and recommend during consultation for balanced, natural results.

Both are botulinum toxin type A neuromodulators with similar clinical efficacy. Xeomin® is a purified (“naked”) formulation without accessory proteins, which some patients and providers prefer. The clinical significance of this difference, including any impact on antibody formation or long-term effectiveness, is still being studied. Both are safe and effective when used appropriately.

Xeomin® is FDA-approved for the temporary improvement of moderate to severe glabellar lines, as well as forehead lines and crow’s feet in adults. Other areas (such as bunny lines, lip flip, or masseter treatment) are considered off-label but are commonly treated based on clinical experience and physician judgment.

Yes—most patients apply makeup the same day if desired. Avoid heavy pressure or rubbing the treated areas for 4–6 hours.

Medical Disclaimer

This information is provided for educational purposes only and is not intended as medical advice. All aesthetic procedures should be performed by appropriately trained and licensed providers under the supervision of a licensed physician where required by Florida law. Individual results may vary. A consultation is required to determine treatment suitability.

Xeomin® (incobotulinumtoxinA) is an FDA-approved neuromodulator manufactured by Merz Pharmaceuticals and is used to temporarily reduce muscle activity in targeted areas. For full prescribing and safety information, visit the official Xeomin® website: https://www.xeominaesthetic.com/